THE FORMATION OF KOJIC ACID BY ASPERGILLUS ORYZAE

Aspergillus oryzae-based cell factory for direct kojic acid production from cellulose

BACKGROUND Kojic acid (5-Hydroxy-2-(hydroxymethyl)-4-pyrone) is one of the major secondary metabolites in Aspergillus oryzae. It is widely used in food, pharmaceuticals, and cosmetics. The production cost, however, is too high for its use in many applications. Thus, an efficient and cost-effective kojic acid production process would be valuable. However, little is known about the complete set o...

Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae

Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in comb...

The amino acid composition of alpha-amylase from Aspergillus oryzae.

o-Amylases have been obtained in crystalline form from a variety of sources covering the animal and vegetable kingdoms. A comparative study of their chemical composition seemed particularly appropriate, since all these enzymes, catalyzing the same chemical reaction, have been shown to possess many common features. The amino acid composition of several cy-amylases has already been described (l-5...

Production of aflatoxins and kojic acid by species of Aspergillus and Penicillium.

Aspergillus oryzae acid proteinase. Purification and properties, and formation of pi-chymotrypsin.

An acid proteinase from Aspergillus oryzae was isolated from a commercial powder by successive (NH4)2SO4 fractionation, acetone precipitation, and ion-exchange chromatography on phosphate- and DEAE-cellulose columns. The purified enzyme was found to be homogeneous by ultracentrifuge-sedimentation analysis (S20, W equal 3.63S), but electrofocusing in polyacrylamide gels and electrophoresis at pH...